Protection from fungal infestation with clotrimazole and neem ext ract. Urea (5%) has been incorporated as a main ingredient in Clo trineem Plus Creme. At this concentration, urea has neither a kera tolytic nor keratoplastic effect, but improves TEWL (transepidermal water loss) and serves as a NMF (natural moisturizing factor). This helps to retain the elasticity and function of the cell membranes. The skin is smooth and sealed, making it difficult or impossible for pathogenic bacteria to penetrate. Neem leaf extract, black cumin, evening primrose oil, clotrimazole and piroctone olamine make the cream an excellent protective and caring, special cream for the be nefit of healthy feet.